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For direct reinforcement of the physical barrier, a synbiotic comprising Clostridium butyricum and chitosan oligosaccharides upregulates tight junction proteins (occludin, claudin-1, ZO-1) and MUC2 while concurrently suppressing TLR4/NF-κB/MAPK signaling, thereby restoring epithelial integrity (Huang et al., 2023)

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Gallstone pancreatitis may be accompanied by peritonitis (Shaffer 2018), a painful and potentially life-threatening condition in which the lining of the inner abdominal wall becomes inflamed (Mayo Clinic 2015