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POP is a condition with a worldwide prevalence of 9% 126 , in which a woman’s pelvic muscles and tissues weaken, resulting in bulging of the pelvic organs (uterus, bladder, rectum) into the vagina 127

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We then treated these cells with a low dosage of erastin, the inhibitor of cysteine transporter xCT 38 , which drastically reduced GSH level and induced replication stress (Fig.7f, g)