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Reference: Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes (2021)

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The one human ulcerative-colitis dataset that regulators have actually reviewed, a rectal-enema pilot, was judged by the FDA to be too limited and poorly reported to establish effectiveness, and notably the drug was not detectable in plasma by that route, with human studies and clinical trials in GI disease still sparse and poorly reported