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“ In this trial, once-weekly cagrilintide-semaglutide for 68 weeks in adults with overweight or obesity was highly effective and led to substantial and clinically meaningful weight loss,” the authors concluded

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However, while the mechanisms of FDA’s regulatory oversight of 503A drug compounding in this context are well-established, it is less clear how the internal deliberations in FDA will evolve given Secretary Kennedy’s public statements, the recent PCAC appointments, and the Administration’s interest in the potential therapeutic benefits of certain peptides even in the face of potential risks