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Adding D-tyrosine can endow short functional cosmetic peptides with an anti-melanin effect, which is of great significance to the research of new cosmetics with whitening/anti-inflammatory and whitening/anti-aging functions ( FIGURE 4 Cyclization of peptides is a strategy that can make peptides have a more stable conformation, enhancing the stability of enzymatic proteolysis and improving the permeability through biological barriers (Karami et al., 2023)

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The discoloration does not stain clothing in most formulations, though patients using higher-concentration creams (4% to 5%) should let the product absorb for 10 to 15 minutes before contact with white fabrics