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OS provides one explanation for the pathogenesis of preeclampsia since it leads to lipid peroxidation accompanied by endothelial dysfunction, i.e., a consequence of periods of ischemia–reperfusion generated from failed spiral artery remodelling during placentation

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We found that the inflammatory factors, Il-1β, Il-6, Cxcl15 , and Tnf-α , which are related to aging, were significantly decreased in the aging-related secretory phenotype (Figure 1B)