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[9] It’s also prudent to be cautious or avoid NAD+ injections if you have a serious uncontrolled medical condition (for example, end-stage liver or kidney disease or severe heart disease), unless your physician specifically determines it’s safe

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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)