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[1] The Human Evidence Gap and Where Research Is Heading The most intellectually honest statement about BPC-157 is this: an unusually robust preclinical literature has established a plausible and broadly consistent mechanistic picture, while the human clinical trial evidence remains essentially absent

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Research demonstrates that GHK-Cu stimulation of collagen synthesis begins at concentrations between 10⁻¹² and 10⁻¹¹ M and maximizes at 10⁻⁹ M, with effects independent of changes in cell proliferation, indicating direct activation of synthetic machinery rather than simply increasing fibroblast numbers